Cancer stem cells are resistant to chemotherapy and consequently remain inside a body even after chemotherapy even after the course of treatment is finished where they can trigger cancer recurrence or metastasis.
A new study by researchers from the A*STAR Institute of Bioengineering and Nanotechnology has found that using nanoparticles to deliver an anti-cancer drug that simultaneously kills cancer cells and cancer stem cells significantly reduces the recurrence and metastasis of lung cancer.
The drug phenformin is very effective against cancer stem cells.It is related to the popular anti-diabetic drug metformin but is 50 times more potent against cancer cell lines.However, phenformin is too toxic in its free form to be administered to patients at the doses required to kill both normal cancer cells and cancer stem cells.
Now, Yi Yan Yang and her colleagues at the Institute of Bioengineering and Nanotechnology in Singapore have found a way to overcome this problem—using self-assembling polymer nanoparticles to deliver the drug .
In the first study to use polymer nanoparticles to deliver phenformin to target both cancer cells and cancer stem cells, Yang
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
The drug phenformin is
very effective against cancer stem cells. It is related to the popular
anti-diabetic drug metformin but is 50 times more potent against cancer
cell lines. However, phenformin is too toxic in its free form to be
administered to patients at the doses required to kill both normal cancer cells
and cancer stem cells. Now, Yi Yan Yang and her colleagues at the
Institute of Bioengineering and Nanotechnology in Singapore have found a
way to overcome this problem—using self-assembling polymer nanoparticles to deliver the drug.
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
The drug phenformin is
very effective against cancer stem cells. It is related to the popular
anti-diabetic drug metformin but is 50 times more potent against cancer
cell lines. However, phenformin is too toxic in its free form to be
administered to patients at the doses required to kill both normal cancer cells
and cancer stem cells. Now, Yi Yan Yang and her colleagues at the
Institute of Bioengineering and Nanotechnology in Singapore have found a
way to overcome this problem—using self-assembling polymer nanoparticles to deliver the drug.
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
The drug phenformin is
very effective against cancer stem cells. It is related to the popular
anti-diabetic drug metformin but is 50 times more potent against cancer
cell lines. However, phenformin is too toxic in its free form to be
administered to patients at the doses required to kill both normal cancer cells
and cancer stem cells. Now, Yi Yan Yang and her colleagues at the
Institute of Bioengineering and Nanotechnology in Singapore have found a
way to overcome this problem—using self-assembling polymer nanoparticles to deliver the drug.
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
The drug phenformin is
very effective against cancer stem cells. It is related to the popular
anti-diabetic drug metformin but is 50 times more potent against cancer
cell lines. However, phenformin is too toxic in its free form to be
administered to patients at the doses required to kill both normal cancer cells
and cancer stem cells. Now, Yi Yan Yang and her colleagues at the
Institute of Bioengineering and Nanotechnology in Singapore have found a
way to overcome this problem—using self-assembling polymer nanoparticles to deliver the drug.
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
The drug phenformin is
very effective against cancer stem cells. It is related to the popular
anti-diabetic drug metformin but is 50 times more potent against cancer
cell lines. However, phenformin is too toxic in its free form to be
administered to patients at the doses required to kill both normal cancer cells
and cancer stem cells. Now, Yi Yan Yang and her colleagues at the
Institute of Bioengineering and Nanotechnology in Singapore have found a
way to overcome this problem—using self-assembling polymer nanoparticles to deliver the drug.
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
simultaneously kills cancer cells and cancer stem cells significantly reduces the recurrence and metastasis of lung cancer
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
simultaneously kills cancer cells and cancer stem cells significantly reduces the recurrence and metastasis of lung cancer
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
Institute of
Bioengineering and Nanotechnology has found that using nanoparticles to
deliver an anti-cancer drug that simultaneously kills cancer cells and
cancer stem cells significantly reduces the recurrence and metastasis of
lung cancer.
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
.
Cancer stem cells are
resistant to chemotherapy and consequently tend to remain in the body
even after a course of treatment has finished, where they can often
trigger cancer recurrence or metastasis. A new study by researchers from
the A*STAR Institute of Bioengineering and Nanotechnology has found
that using nanoparticles to deliver an anti-cancer drug that
simultaneously kills cancer cells and cancer stem cells significantly
reduces the recurrence and metastasis of lung cancer.
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
Read more at: http://phys.org/news/2015-03-nano-packages-anti-cancer-drug-delivery.html#jCp
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